ICIUAIC

University Professor
Ionel MANGALAGIU

Science Research Department, CERNESIM Center

Areas of expertise:

  • studies concerning design, synthesis and properties of new azaheterocyclic derivatives
  • synthesis of new newly highly fluorescent materials, nano(bio)materials, nano-electronics and nano-devices (logic gates including), new chemical captors (chemosensors)
  • green chemistry (environmentally friendly) methods applied in chemistry: microwave and ultrasounds assisted reactions
  • investigations of the medical-pharmaceutical properties of the azaheterocyclic compounds

Scientific profile:

Contact:

Research field: Heterocyclic Compounds with three area of expertise: Chemistry and Health – the development of new useful reactions for the synthesis of heterocyclic compounds, and in particular, reactions involving reactive species such as cycloimmoniu ylides. The main outcomes of these directions are:  new nitrogen heterocycles biologically active [antimicrobials (antituberculosis including), anticancer and grow up factors for agriculture], new nanobiomaterials with and without nitrogen heterocycle moieties, etc.; Chemistry and Nanoscience – in this field our efforts are orientated in the area of oxa- and oxaaza- coronands, nano-electronics and nano-devices, nanobiomaterials (for dentistry including), new highly fluorescent materials, chemical captors (chemosensors); Chemistry and Sustainable Development – microwave and ultrasounds assisted reactions; these technologies allow us to develop environmental friendly methods, with lower waste and environmental friendly impact [“green” chemistry].

Coordinated projects:

International

  • 1. Biologically active compounds with terpenoid and azaheterocycle skeleton through conventional and nonconventional methods, Grant bilateral Romania – Moldova, Grant nr. 418/02.06.2010, ANCS, PN-II, Modul III,
    Duration 2010-2012,
    Value 10.000,00 Euro
  • 2. Photocatalytic Clusters Complexes for Artificial Photosynthesis Applications, Grant FP7- People-2009, program IRSES, Grant no. 246902/2009,
    Duration 2010-2013,
    Value 194.400,00 Euro http://www.2020-horizon.com/PCAP-Photocatalytic-Cluster-Complexes-for-Artificial-Photosynthesis-Applications(PCAP)-s6829.html
  • 3. Synthesis of Highly Fluorescent Materials Through Eco-friendly Methods, NATO PROGRAMME SECURITY THROUGH SCIENCE, Grant NATO- Collaborative Linkage Grant, Grant no. PDD(CP)-(CBP.EAP.CLG 982499)/20.11.2006,
    Duration 2006-2007,
    Value 5.000,00 Euro
  • 4. Designing novel materials for nanodevices - from Theory to Practice (NanoTP), European Union- FP7 program COST, Action MP0901,
    Duration 2010-2012,
    Value 200.000,00 Euro http://www.cost.eu/COST_Actions/mpns/Actions/novel_materials_for_nanodevices
  • 5. Targeted chemotherapy towards diseases caused by endoparasites, European Union- FP7 program COST, Action MP1307,
    Duration 2014-2018,
    Value 200.000,00 Euro http://www.cost.eu/COST_Actions/cmst/Actions/CM1307

National

  • 1. Development of a new generation of azaheterocyclic hybrid skeleton antimicrobial agents using environmentally friendly methods, PN-III-P4-ID-PCE-2020-0371, Contract No. 115/202, MEC- UEFISCDI,
    Duration 2021-2023,
    Value 1.200.000,00 lei
  • 2. Excelency research in Romania in the firld of antimicrobial compounds (Acronym: CED-Antim), MEC- CNCSIS, Contract CNFIS-FDI-2019-0129,
    Duration 2019,
    Value 352.000,00 lei
  • 3. Excelency research in Romania in the CERNESIM research unit (Acronym: CER-CE), Contract MEC-CNCSIS, CNFIS-FDI-2018-0102,
    Duration 2018,
    Value 306.600,00 lei
  • 4. New polifunctional nitrogen derivatives (heterocycles, podants and macrocycles) as smart versatile building blocks for multiple tasks, MEC- CNCSIS, PN-II-DE-PCE-2011-3-0038, Contract No. 268/2011,
    Duration 2012-2016,
    Value 1.500.000,00 lei
  • 5. Chemosensors with Macrocyclic Skeleton, MEC- CNCSIS,. Contract No. 88/2008,
    Duration 2009-2011,
    Value 450.000,00 lei
  • 6. Macrocycles of Type Coronand Through Conventional and Nonconventional Methods (Microwave and Ultrasounds), Grant CEEX, MEC- MATNANTEC, Contract No. 36/2005,
    Duration 2005-2008,
    Total value 11,5 miliarde ROL
  • 7. Obtaining, Physical-Chemical and Biological Characterization of Some Steroid-Glicosid Biopreparations of Vegetal Origin, Grant CEEX, MEC- BIOTECH, Contract No. 49/2005,
    Duration 2005-2008,
    Total value 15 miliarde ROL,
  • 8. New Anti-HIV and Anti-fungus Nanocompounds Incorporated in Cyclodextrine, Grant CEEX, MEC- CERES- 06-D11-106, Contract No. CERES- 06-D11-106/2006,
    Duration 2006-2008,
    Total value 15 miliarde ROL
  • 9. New Research in the Class of Cycloimmonium Ylides (Nitrogen Ylides). Syntheses, Structure, Reactivity and Practical Applications, cod CNCSIS 109/1999, World Bank (70%) & Romanian Government (30%),
    Duration 1999-2001,
    Value 90.000,00 $ (US)
  • 10. Using Nonconventional Methods in Organic Chemistry: Microwave and Ultrasounds, CNCSIS, Grant A, cod 1155,
    Duration 2006-2008,
    Value 95.000,00 Lei
  • 11. Microwave Assisted Reactions in the Heterocycle Series, CNCSIS, Grant A, cod 1322,
    Duration 2003-2005,
    Value 383.000,00 Lei
  • 12. Research concerning obtaining, structure and reactivity of diazinium ylides, Grant A, CNCSIS, Grant no. 15, tema 23,
    Duration 1998,
    Value 6.000.000,00 Lei